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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Andrea di Bello
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



Articoli con TAG: chronic liver disease

Comparison of albumin-bilirubin grade with Child-Pugh and Model for End Stage Liver Disease scores in chronic liver disease
<p>Introduction: chronic liver diseases are characterized by injury to hepatocytes, chronic inflammation and progressive substitution of liver parenchyma by scar tissue or fibrosis. Albumin-bilirubin grade (ALBI) includes serum albumin and bilirubin levels, two most commonly performed and cost-effective parameters measured in the Clinical Laboratory. This study aims to establish an association between ALBI grade and Model for End stage Liver Disease (MELD) and Child-Pugh (CP) scores among chronic liver disease patients.<br />Methods: after ethical approval, information such as age, gender, provisional diagnosis, serum albumin and serum total bilirubin levels, prognostic scores of patients with liver disease were obtained from patient records. Albumin-bilirubin grading system was calculated as following: [log10 bilirubin (&mu;mol/L) &times; 0.66] + [albumin (g/L) &times; &minus;0.0852].<br />Results: this cross-sectional descriptive study recruited 100 patients with chronic liver disease and 100 healthy controls. Alcoholism was the common aetiology among the cases. ALBI was calculated; the mean (SD) grade among cases and controls were -0.94 (0.15) and -3.17 (0.23) respectively with a p-value of &lt;0.001.There was statistically significant difference in ALBI grades between CP scores B and C (p value = 0.001). Pearson&rsquo;s correlation between MELD score and ALBI grade showed a statistically significant correlation (r = 0.723 with significance 0.001).<br />Discussion: our study demonstrated that there was a significant association between ALBI grade and the most commonly used prognostic scores such as CP and MELD.</p>
Biochimica Clinica ; 17(1)
Contributi Scientifici - Scientific Papers