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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
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Marcello Ciaccio Italy
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Giuseppe Lippi Italy
☩Howard Morris Australia
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Giuseppe Agosta

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Arianna Lucini Paioni
Biomedia srl
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email: biochimica.clinica@sibioc.it



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Articoli con TAG: biomarkers

Comparative study of galectin-3, brain natriuretic peptide, cystantine C and high sensitivity troponin determinations in the diagnosis of heart failure in elderly italian males
<p>Introduction: heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care issues makes it a challenging chronic disease to diagnose and manage. Our study is aimed to evaluate a multi-markers approach in diagnosis of HF in aged males.<br />Methods: 68 Italian males aged &gt;65 years have been enrolled; 25 were patients with heart failure (HF) and 43 were healthy controls. In all the subjects, measurements of high sensitivity troponin I (TNI), galectin-3 (GAL), cystatin C (CYS) and brain natriuretic peptide (BNP) were performed using routine methods.<br />Results: in patients with HF, mean concentrations of TNI, GAL, CYS and BNP were significantly higher (p&lt;0.001) than values observed in controls subjects. Only BNP and GAL showed a correlation with NHYA stage of HF. In this study, GAL and BNP demonstrated better diagnostic perfomamces to differentiate of HF patients from controls subjects.<br />Conclusions: our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratory diagnosis of HF in elderly males.</p>
Biochimica Clinica ; 43(4) 399-405
Contributi Scientifici - Scientific Papers
 
La metilazione del DNA nella diagnostica: stato dell’arte e prospettive
DNA methylation in diagnostics: state of the art and perspectives
<p>DNA methylation is the most known and studied among the epigenetic modifications; these are chemical modifications occurring on DNA or histone proteins, able at modifying the transcriptional efficiency of genes. DNA methylation consists in the binding of a methyl group (-CH3) on the carbon n. 5 of a cytosine moiety. Recently, it has been demonstrated that methylated cytosines can be further modified to hydroy-methyl-cytosines, but it is still unclear whether this transformation is just a demethylation intermediate or it canretain the functional role of an independent epigenetic modification. At first, DNA methylation has been studied for itsphysiological role in the regulation of one expression during the different stages of the cell life, particularly duringdifferential and embryogenesis. Then, during the last thirty year, it has been shown that the epigenetic modifications,particularly DNA methylation, are involved in the onset and progression processes of some pathologies. The role of DNA methylation in cancer processes is known since a long time, whereas only recently it becomes evident that this epigenetic modification is a component of some degenerative and aging-associated pathologies, particularly in neurodegenerative and inflammatory processes. Due to the incredible technical advances developed in the last years, it is now possible to study in detail the methylation pattern of a gene sequence with single cytosine resolution, rapidly and with high accuracy and precision. Besides allowing the rapid evolution of our knowledge of the physio-pathological states in which DNA methylation has a functional role, this favourable condition also allows us to consider the possible use of DNA methylation as diagnostic biomarker in different pathologies.</p>
Biochimica Clinica ; 43(4) 413-420
Opinioni - Opinions