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Articoli con TAG: MGUS

Espressione e valore prognostico del ciclo cellulare e delle aneuploidie nel mieloma multiplo e nella gammopatia monoclonale di significato indeterminato
Expression and prognostic value of cell cycle and aneuploidy in multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS)
<p>In this study, we used multiparameter flow cytometry (MFC) to investigate old and new plasma cell (PC) markers, such as the extrusion pumps of drugs, cluster of differentiation 243 (CD243) and citochemokine receptors (CD197, CD191, CD192, CD196, CD183, CD184, CD126) involved in cellular interactions, locomotion, adhesion and invasion. We studied the different expression of PC in 55 samples of bone marrow of patients affected by MM and MGUS, using MFC and immunomagnetic sorting. The incidence and prognostic significance of the analysis of the cell cycle and aneuploidy were evaluated in order to support the efficacy of MFC. By analysing the immunophenotypic receptor molecules expression and extrusion pumps, we found that CD243, CD192, CD183, CD191 and CD196 showed increased expression in cases of MM, whereas an increased expression of CD197, CD184 and CD126 emerged in MGUS samples. In comparing neoplastic and normal PC in MM samples, we found an increased expression of all receptors on the surface of neoplastic PC. Cell cycle and aneuploidy analysis of all samples showed a pseudodiploid condition with a more difficult prognosis, even considering the old age of patients.</p>
Biochimica Clinica ; 41(3) 228-234
Contributi scientifici - Scientific papers
 
Gammopatie monoclonali: quadri clinici principali e ruolo del laboratorio
Monoclonal gammopathies: main clinical pictures and role of the clinical laboratory
<p>The finding of a monoclonal gammopathy both by chance and upon clinical suspicion is becoming more and more frequent and requires in-depth clinical, laboratory and instrumental analyses in order to establish the underlying disease, if any. In the last two decades the improvement of the diagnostic tools has led to the identification and precise definition of several clinical entities pathogenetically linked to the monoclonal gammopathy, thus shrinking the field of the &quot;monoclonal gammopathy of undetermined significance&quot;. Such a striking improvement relies on the increasing sensitivity and accuracy of old analyses and availability of new ones (such as the serum Free Light Chain assay). Currently, data from the clinical biochemistry laboratory provide important clues to the diagnosis and prognosis, and are also crucial for monitoring the therapy. These new achievements, along with the availability of new therapeutic options, allowed a significant, sometimes dramatic improvement of the prognosis of many of the gammopathy-related diseases. In this review the main clinical pictures are described along with the contribution of the clinical biochemistry laboratory to the definition of the diagnosis, the risk profile and the monitoring of the specific diseases.</p>
Biochimica Clinica ; 43(4) 366-383
Rassegne - Reviews
 
Gammopatie monoclonali di significato clinico
Monoclonal gammopathies of clinical significance.
<p>This Opinion is aimed to comment and emphazise the main points raised in a seminal paper published in 2018 in Blood. The paper deals with a number of severe diseases caused by small lymphoid/plasma cell clones. These clones affect different organs by means of the biological properties of the clonal cells themselves and/or of their secretion products such as monoclonal immunoglobulins, cytokines and other molecules. More importantly, the paper also deals with the pathogenetic mechanisms involved in the organ damage and sheds light on most of them. The present comment aims to bring attention to these diseases, but it does not encompass the whole matter. We suggest that the readers involved in this matter refer to the paper in its original version.</p>
Biochimica Clinica ; 43(4) 421-423
Opinioni - Opinions