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BC: Articoli scritti da C. Villa

Un raro caso di mesotelioma multicistico del peritoneo associato ad aumento di CA 125 e CA 19.9 nel siero
A rare case of benign multicystic mesothelioma of the peritoneum associated to CA 125 and CA 19.9 elevations in serum
S. Ferraro  |  R. Mozzi  |  C. Villa  |  M. Crespi  |  M. Panteghini  | 
<p>Markedly increased CA 125 and CA 19.9 concentrations in serum are considered specific&nbsp;enough to reliably identify malignant cancers (ovarian and gastrointestinal tumours, respectively), although a&nbsp;consistent body of literature has reported marker elevations in several benign conditions. Here we report the case of&nbsp;a woman in post-menopausal status, with a previous history of hysterectomy, presenting with a 12-cm pelvic mass at&nbsp;sonography and serum CA 125 and CA 19.9 concentrations &gt;400 kU/L. One month after initial presentation, she&nbsp;underwent surgical evaluation for laparoscopy, repeating marker determinations. Concentrations of CA 125 and CA&nbsp;19.9 were still elevated, but decreased if compared with the previous data (~200 kU/L). Magnetic resonance imaging&nbsp;characterized a multicystic mass in the mesentery, allowing to hypothesize a benign multicystic mesothelioma of the&nbsp;peritoneum (BMMP). The laparoscopy revealed multiple cysts, some of them resulting in colliquation, associated to&nbsp;ascites. Histological examination of biopsy specimens confirmed BMMP as composed of multiple, thin-walled,&nbsp;irregularly spaced cysts lined by flattened and cuboidal mesothelial cells. The cystic colliquation was though as the&nbsp;main cause for decrease in marker concentrations. To our knowledge, this is the first case of BMMP associated with&nbsp;significantly increased concentrations of CA 125 and CA 19.9 and their decrease before any surgical treatment.</p>
Biochimica Clinica ; 37(3) 241-245
Casi Clinici - Case Report