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Giuseppe Agosta

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BC: Articoli scritti da R. Valle

Effect of dabigatran and rivaroxaban treatment on a prothrombinase-based assay for assessment of activated C protein resistance
G. Gessoni  |  S. Valverde  |  R. Valle  | 
<p>We present a report about the interference due to factor IIa and factor Xa direct oral inhibitors on activated C protein&nbsp;resistance ratio (APCr), evaluated with a prothrombinase-based assay, in a patient heterozygous for factor V Leiden&nbsp;treated first with dabigatran and then with rivaroxaban. In this patient dabigatran increased the APCr ratio to a degree compatible with values observed in homozygous wild-type carriers, thus causing a potential misdiagnosis. We also&nbsp;found that rivaroxaban therapy was effective in lowering the APCr ratio.</p>
Biochimica Clinica ; 39(1) 073-075
Casi clinici - Case report