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BC: Articoli scritti da R. Valle

Effect of dabigatran and rivaroxaban treatment on a prothrombinase-based assay for assessment of activated C protein resistance
G. Gessoni  |  S. Valverde  |  R. Valle  | 
<p>We present a report about the interference due to factor IIa and factor Xa direct oral inhibitors on activated C protein&nbsp;resistance ratio (APCr), evaluated with a prothrombinase-based assay, in a patient heterozygous for factor V Leiden&nbsp;treated first with dabigatran and then with rivaroxaban. In this patient dabigatran increased the APCr ratio to a degree compatible with values observed in homozygous wild-type carriers, thus causing a potential misdiagnosis. We also&nbsp;found that rivaroxaban therapy was effective in lowering the APCr ratio.</p>
Biochimica Clinica ; 39(1) 073-075
Casi clinici - Case report
 
Comparative study of galectin-3, brain natriuretic peptide, cystantine C and high sensitivity troponin determinations in the diagnosis of heart failure in elderly italian males
<p>Introduction: heart failure (HF) has been defined a modern pandemic. The complex array of physiologic,psychological, social and health care issues makes it a challenging chronic disease to diagnose and manage. Ourstudy is aimed to evaluate a multi-markers approach in diagnosis of HF in aged males.<br />Methods: 68 Italian males aged &gt;65 years have been enrolled; 25 were patients with heart failure (HF) and 43 werehealthy controls. In all the subjects, measurements of high sensitivity troponin I (TNI), galectin-3 (GAL), cystatin C(CYS) and brain natriuretic peptide (BNP) were performed using routine methods.<br />Results: in patients with HF, mean concentrations of TNI, GAL, CYS and BNP were significantly higher (p&lt;0.001) thanvalues observed in controls subjects. Only BNP and GAL showed a correlation with NHYA stage of HF. In this study,GAL and BNP demonstrated better diagnostic perfomamces to differentiate of HF patients from controls subjects.<br />Conclusions: our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratorydiagnosis of HF in elderly males.</p>
Biochimica Clinica ; 17(1)
Contributi Scientifici - Scientific Papers