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BC: Articoli scritti da P.-E. Sottas

Il passaporto biologico dell’atleta
The athlete biological passport
P.-E. Sottas  |  N. Robinson  |  O. Rabin  |  M. Saugy  | 
<p>In elite sports, the growing availability of doping substances identical to those naturally produced by the human body&nbsp;seriously limits the ability of drug-testing regimes to ensure fairness and protection of health. The Athlete Biological&nbsp;Passport (ABP), the new paradigm in testing based on the personalized monitoring of biomarkers of doping, offers&nbsp;the enormous advantage of being independent of this endless pharmaceutical race. Doping triggers physiological&nbsp;changes that provide physiological enhancements. In the same way that disease-related biomarkers are invaluable&nbsp;tools that assist physicians in the diagnosis of pathology, specifically selected biomarkers can be used to detect&nbsp;doping. The ABP is a new testing paradigm with immense potential value in the current climate of rapid advancement&nbsp;in biomarker discovery. In addition to its original aim of providing proof of a doping offense, the ABP can also serve&nbsp;as a platform for a Rule of Sport, with the presentation before competition of the ABP to objectively demonstrate that&nbsp;the athlete will participate in a healthy physiological condition that is unaltered by performance enhancing drugs.&nbsp;Finally, the decision-support system used today for the biological monitoring of world top-level athletes can also be&nbsp;advantageously transferred to other areas of clinical practice to reach the goal of personalized medicine.</p>
Biochimica Clinica ; 37(4) 318-325
Il meglio di Clinical Chemistry - Clinical Chemistry highlights