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Maria Stella Graziani

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Giuseppe Agosta

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Arianna Lucini Paioni
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email: biochimica.clinica@sibioc.it



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BC: Articoli scritti da G.M. Sancesario

Ferritina e siderofagi liquorali nella diagnosi di siderosi cerebrale superficiale
Cerebrospinal fluid ferritin and siderophages in the diagnosis of superficial cerebral siderosis
<p>We observed&nbsp;a case of superficial siderosis (SS) of the central nervous system caused by an hemorrhagic trauma forty years&nbsp;before. We questioned whether SS was the stabilized effect of a remote bleeding or an evolutionary process&nbsp;indirectly related to the trauma. Moreover, we aimed to evaluate whether an iron chelator can affect the level of iron&nbsp;deposition. Magnetic Resonance (MRI) demonstrated iron accumulation mainly on the surface of the cerebellum and&nbsp;brain stem. Cerebrospinal fluid (CSF) microscopic analysis revealed few siderophages; CSF ferritin level was 76&nbsp;ng/mL (reference value &lt;12). After treatment with an iron chelator (deferiprone) for three months, MRI was&nbsp;unchanged, but the CSF ferritin was about 20% less. The presence of few siderophages supported the hypothesis of&nbsp;a persistent subarachnoid microbleeding. CSF ferritin, as an iron deposition index, allowed a diagnosis of SS and a<br />more sensitive evaluation of the efficacy of the treatment than the MRI.</p>
Biochimica Clinica ; 39(6) e19-e21
Casi clinici - Case report