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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
☩Howard Morris Australia
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
☩Jill Tate Australia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


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Giuseppe Agosta

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Arianna Lucini Paioni
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email: biochimica.clinica@sibioc.it



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BC: Articoli scritti da F. Salvatore

La biologia molecolare clinica nella valutazione e prevenzione del rischio cardiologico nell’attività sportiva e nell’attività motoria intensa
Clinical molecular biology in the assessment and prevention of cardiological risk in case of participation in sports activity and intense physical activity
<p>We review the clinical molecular biology approach for the prevention of cardiological diseases, essentially via risk assessment at personal level by DNA analysis. Intense physical activity, particularly during athletic performances, can result in syncope or even cardiac arrest, often followed by sudden<br />cardiac death. An approach to the prevention of such tragic events is predictive medicine (presence of pathogenic mutations in cardiac genes), besides the conventional tools used in cardiology (mainly electro and echocardiogram under stress conditions). Accordingly, we list the major cardiac diseases and their related genes and derivative proteins which are instrumental for normal heart function. Alterations can occur in ion channel genes, in genes<br />encoding desmosomial and junctional proteins, sarcomeric and Z-disc proteins, proteins for the cytoskeleton at the nuclear envelope, and in genes encoding mitochondrial proteins. Thus, we constructed two sets of gene panels: one set to discriminate among confounding heart diseases, and another set based on a cost-benefit criterion according to the most or less frequent genes bearing pathogenic variants that entail a higher or lower predisposing risk. This<br />approach should be used to monitor pre-participation athletes and also amateurs who belong to families in which at least 1-2 subjects are affected by cardiac alterations. The risk should be identified with the aim to monitor subjects in order to prevent cardiac arrest and even sudden cardiac death.</p>
Biochimica Clinica ; 43(1) 024-043
Rassegne - Review
 
Meccanismi epigenetici nella patogenesi dell’allergia al latte vaccino
Epigenetics and cow’s milk allergy: implication for pathogenesis
<p>Cows&rsquo; milk allergy (CMA) is one of the most&nbsp;frequent allergies in child, often occurring quite soon after birth. Recent years have been featured by an increasing&nbsp;prevalence of CMA that can often be the first appearance of the so-called &ldquo;atopic march&rdquo;. Typically, CMA is featured&nbsp;by immunoglobulin E (IgE)-mediated reactions; however, the pathogenetic basis of IgE-mediated CMA is not yet&nbsp;completely understood. Recent evidences suggest that epigenetic factors, such as DNA methylation and regulatory&nbsp;non-coding RNAs could play a role in allergic diseases, including CMA. Here, we review the state of the art regarding&nbsp;the involvement of some epigenetic modifications in allergic diseases, and especially in CMA. We describe that&nbsp;epigenetic derived molecules, in addition to be pathogenetic factors contributing to typical CMA allergic phenomena,&nbsp;could also serve to produce molecules which may act as novel, specific and easily accessible biomarkers for CMA&nbsp;diagnosis and monitoring.</p>
Biochimica Clinica ; 42(2) 103-111
Rassegne - Reviews
 
In ricordo di Giovanni Ceriotti
In memory of Giovanni Ceriotti
Biochimica Clinica ; 42(1) 82
Notizie SIBioC - SIBioC News
 
Application of array-Comparative Genomic Hybridization analysis in immune-virotherapy approach
<p>Introduction: oncololytic adenoviruses (OAds), viruses constructed to replicate in tumor cells, improve the outcome of cancer therapy in some cases, such as sarcomas. However, the molecular heterogeneity of tumors requires specific and personalized cancer treatments in order to set up more adequate and effective therapies.<br />Methods: by using the array Comparative Genomic Hybridization (array-CGH), a molecular approach method, we aimed to identify chromosomal aberrations or Copy Number Variants (CNVs) in three different tumor cell lines: HCT116, SW872 and A2058 selected for their Coxsackievirus and Adenovirus receptor (CAR) expression profile.<br />Results: the cells showed several duplications of genes involved in replicative Adenovirus cycle (binding, internalization, escape) in the core transport, and in the escape of the viral DNA from the capsid.<br />Conclusion: in this study, our aim was to identify chromosomal alterations in genes involved in the OAd replication cycle process. Array-CGH method could be useful to design a platform for a screening analysis in order to identify mutations that can contribute to oncolytic virotherapy approach generating a personalized strategy for tumor suppression.</p>
Biochimica Clinica ; 17(1)
Contributi Scientifici - Scientific Papers
 
Il ricordo di un Maestro della Medicina di Laboratorio: Giorgio Federici
Biochimica Clinica ; 17(1)
Notizie SIBioC - SIBioC News