Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
☩Howard Morris Australia
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
☩Jill Tate Australia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


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Responsible Editor
Giuseppe Agosta

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Arianna Lucini Paioni
Biomedia srl
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email: biochimica.clinica@sibioc.it



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BC: Articoli scritti da A. Pocognoli

Approfondimenti necessari sul liquido cerebro spinale
Insights on the cerebrospinal fluid
<p>The human parechoviruses (HPeV) have recently been recognized as emerging pathogenic microorganisms causing a broad pattern of diseases including sepsis and meningitis in children. A born-at-term, 33-day-old child, was admitted to the hospital with fever, irritability, and loss of appetite. Results of physical examination and routine blood chemistry were unremarkable (no lung rales or skin rashes; normal hemoglobin and leukocyte and platelets counts) with the only exception of an elevated procalcitonin serum level. Examination of the patient&rsquo;s cerebrospinal fluid (CSF) showed pleocytosis, normal glycorrhachia and a mild increase of proteins. Blood and CSF cultures were negative. When tested with a commercial multiplex PCR technology (FILMARRAY&reg;- Biomerieux), CSF turned out positive for the HPeV. Rapid identification of HPeV may contribute to reduce the laboratory turnaround time and improve clinical management. HPeV should be included in the differential diagnosis of young children with central nervous system symptoms and sepsis-like illness.</p>
Biochimica Clinica ; 44(1) e3
Casi Clinici - Case Report
 
L’immunosottrazione può rivelarsi più utile dell’immunofissazione nella tipizzazione di componenti monoclonali IgAl
Immunosubtraction technique is sometimes more useful than immunofixation for typing IgAl monoclonal components
<p>The characterization of a monoclonal component involves a serum protein electrophoresis and the immunotyping. &nbsp;Serum samples from 6 patients showed a slight anomalous peak in the b-region of the serum electrophoresis. &nbsp;Using immunofixation, only a heavy chains were typed, suggesting an a heavy chain disease.&nbsp;In 4 of these cases, the problem was observed when the monoclonal component was detected for the first time, with a potential risk of misdiagnosis.&nbsp;The 4 cases account for 5% of new monoclonal component IgA detected in the considered period.&nbsp;Although there are several reports on the lower sensitivity of immunosubtraction in comparison with immunfixation, we report here some exceptions about the usefulness of immunosubtraction in the identification of small IgAl monoclonal components.</p>
Biochimica Clinica ; 39(5) 326-330
Contributi scientifici - Scientific Papers