Maria Stella Graziani

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BC: Articoli scritti da S. Pichini

Documento di consenso Gruppo di Studio di Farmacotossicologia Clinica e Doping SIBioC e Gruppo Tossicologi Forensi (GTFI). Modalità per lo svolgimento di indagini di laboratorio per la determinazione delle sostanze d’abuso
Consensus document of the Study Group on Clinical Pharmacotoxicology and Doping of Italian Society ofClinical Biochemistry and Italian Forensic Toxicologists Group (GTFI) – for laboratories involved in thedetermination of substances of abuse
<p>The greatest workload for the laboratories performing pharmacotoxicological tests remains the routine activity for detection and measurement, in different biological matrices, of psychotropic substances such as opiates, cocaine, cannabinoids, amphetamines, methadone, buprenorphine and ethyl alcohol. In addition to the investigations requested for clinical reasons, the requests to the pharmacotoxicological laboratories may also include medico-legal investigations, whose variety and complexity contributed to the adoption of personalized and extremely diverse operating modalities implemented in the Italian laboratories. The purpose of this document is to provide the Laboratories of the National Health Service in Italy that are planning to carry out or that already perform determination of drugs of abuse for medico-legal purposes, with recommendations at national level that take into account the &ldquo;good laboratory practices&rdquo; recognized at the international level in order to perform accurate and precise analytical tests so that they can meet the requirements necessary to provide a high quality and legally unassailable service.</p>
Biochimica Clinica ; 43(4) 449-452
Documenti SIBioC - SIBioC Documents
Droghe e alcol: tempo di armonizzazione
Alcohol and drugs: time for harmonization
Biochimica Clinica ; 39(2) 092-093
Editoriale - Editorial
“Smart drugs”, le nuove droghe sul web: due casi di intossicazione acuta
“Smart drugs”, the new drugs on the web: two cases of acute intoxication
<p>New psychoactive substances that&nbsp;in some cases are not subjected to any legal restriction recently overwhelmed web market. They were historically&nbsp;defined &ldquo;smart drugs&rdquo;: substances either natural or synthetic with alleged psychoactive effects as well as effects on&nbsp;sexual performance. We present here two intoxication cases: the first concernes a male subject hospitalized for deep&nbsp;unconsciousness, who took in yohimbine and kawaine, two psychoactive alkaloids present in herbal preparations of&nbsp;Pausinystalia yohimbe and Piper methysticum, sold on the sexy shop websites; the second concernes a female with&nbsp;a previous history of drug poliabuse, hospitalized for dysphoric syndrome/hallucinations, who took in benzydamine,&nbsp;a local anesthetic and analgesic drug, contained in an antibacterial gynecological powder that in oral mis-overdosage&nbsp;acts as a deliriant and central nervous system stimulant.</p>
Biochimica Clinica ; 38(3) 268-271
Casi clinici - Case report
Considerazioni sulle matrici biologiche idonee alla valutazione dell’“attualità d’uso di sostanze illecite” ai fini degli articoli 186 e 187 del nuovo Codice della Strada
Thoughts on biological matrices suitable for the assessment of "current use of illicit drugs" according to articles 186 and 187 of new Rules of the Road
R. Pacifici  |  P. Gori  |  L. Martucci  |  S. Pichini  | 
<p>Data on detection times of drugs of abuse in different biological&nbsp;matrices are based on pharmacokinetic studies in healthy volunteers during controlled clinical trials. The detection&nbsp;times mainly depend on the dose, route of administration, frequency of consumption (acute or chronic), detection limit&nbsp;of the assay employed for substance determination and matrix being analyzed (blood, saliva, urine, hair). Literature&nbsp;data agree that biologic effects drugs of abuse exert on the body match the presence of such substances and/or their&nbsp;metabolites in blood and/or saliva. Only after hepatic metabolism and renal excretion processes substances and/or&nbsp;their metabolites appear in urine, the last compartment from which substances are eliminated from the body. Hair&nbsp;analysis provides information on consumption of drugs of abuse in months prior to cutting of hair lock. These findings&nbsp;have relevance for the purposes of articles 186 and 187 of new Rules of the Road. Whereas in the case of alcohol,&nbsp;the law specifies in detail the biological matrix and the type of equipment to be used for the determination, for drugs&nbsp;of abuse it is unclear on what matrix is more appropriate to evaluate the presence of a substance of abuse and/or its&nbsp;metabolites in order to establish or better confirm driving under the influence of these substances. In this contribution,&nbsp;based on pharmacokinetic and pharmacodynamic considerations, we aim to reaffirm the most suitable biological&nbsp;matrices to determine the &quot;current use of illicit drugs&quot;.</p>
Biochimica Clinica ; 38(1) 27-31
Opinioni - Opinions
Determinazione di sostanze farmacologicamente attive lecite e illecite nel latte materno mediante cromatografia liquida - spettrometria di massa tandem
Liquid chromatography-mass tandem spectrometry assay (LC-MS/MS) for licit and illicit drugs in breast milk
Biochimica Clinica ; 35(4) 285