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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Andrea di Bello
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da B. Peruzzi

Un caso clinico di linfocitosi persistente
Persistent Lymphocytosis
B. Jance \| B. Salvadori \| F. Cesari \| A. Rogolino \| B. Peruzzi \| R. Caporale \| A. Fanelli \|
<p>Persistent Polyclonal Binucleated B-cell Lymphocytosis (PPBL) is a rare, benign hematological disorder characterized by a chronic polyclonal B-cell lymphocytosis with binucleated lymphocytes. We report the clinical case of a young woman with lymphocytosis who presented binucleate lymphocytes at the morphological examination of the peripheral venous blood smear. Flow cytometry immunophenotyping performed in peripheral blood showed a polyclonal lymphocyte B subpopulation. Serological tests were negative for viral infections. Because of its benign and indolent course, the diagnoses of PPBL is important in order to avoid unnecessary diagnostic procedures and therapies.</p>
Biochimica Clinica ; 43(4) e38-e40 Casi Clinici - Case Report

Valutazione multicentrica dei conteggi cellulari ottenuti con 8 analizzatori ematologici automatici
Multicenter evaluation of blood cell counts on 8 automated hematology analyzers
S. Buoro \| S. Pipitone \| A. Fanelli \| S. Francione \| G. Da Rin \| A. Di Fabio \| A. Marini \| A. Papa \| M. Seghezzi \| A. Benegiamo \| B. Peruzzi \| M. Borin \| F. Siviero \| L. Francioni \| T. Lari \| F. Balboni \| M.L. Ciardelli \| Francesco Dima, Luca Germagnoli, Maria Gioia, Antonio La Gioia \| Gruppo di Studio SIBioC - Medicina di Laboratorio Diagnostica ematologica \|
<p>The cellular analysis performed on hematology analyzers is based on the interaction of cells with electrical or optical signals. The heterogeneity of adopted methods and technologies by different analyzers can translate in a lack of homogeneity in analytical performance. This study compares 8 hematological analyzers vs. optical microscopy (OM) and, where possible, also compares the analyzers among each other. Correlations were assessed by Pearson's coefficient of correlation, Passing and Bablock regression and Bland-Altman bias plot analysis. The comparison among analyzers regarding leukocyte differential counts showed a good level of agreement, except for the basophil cell count. For this “critical population”, the bias ranged from -5,8% (Cell-Dyn Sapphire vs. XN-9000) to 30,6% (Advia 2120i vs. XE-2100). The comparison between automated differential leukocyte counts and OM showed also a good level of agreement, with a bias ranging from -0,9% to 8.9%. The bias for basophil cell count was however very high (79.5%).</p>
Biochimica Clinica ; 40(3) 195-203 Contributi scientifici - Scientific Papers