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BC: Articoli scritti da R. Penitente

Distribuzione delle concentrazioni di lipocalina associata alla gelatinasi dei neutrofili (NGAL) nelle urine di soggetti con funzionalità renale in ambito fisiologico
Urinary neutrophil gelatinase-associated lipocalin (NGAL) concentrations in subjects with preserved renal function
R. Penitente  |  C. Zuppi  |  S. Baroni  | 
<p>The role of NGAL as an early and sensitive biomarker of acute kidney injury (AKI) has been confirmed in&nbsp;several studies, but its sensibility in highlighting subclinical renal tubular dysfunction is still uncertain. The NGAL&nbsp;biological variability, the lack of specificity of immunoassays and the extra renal sources of NGAL can generate&nbsp;difficulties in evaluating NGAL basal values and in establishing diagnostic cut-offs. Moreover, the optimal measurement&nbsp;unit to report NGAL values is still controversial. The aim of this study was to measure urinary NGAL in a population with&nbsp;preserved renal function in order to evaluate the reference interval, expressing results as both mass concentration (<span style="font-family:symbol">&mu;</span>g/L)&nbsp;and ratio to urinary creatinine (<span style="font-family:symbol">&mu;</span>g/g). 170 apparently healthy subjects (90 men and 80 women, ranging from 31 to 80&nbsp;years) with normal renal function were enrolled in the study. NGAL was measured in the second morning void urinary&nbsp;sample by Abbott reagents on Architect analyzer; creatinine was assayed by enzymatic method on Roche Cobas C311.&nbsp;The distribution of NGAL values in the population was highly asymmetric, either expressed as mass concentration&nbsp;(median, 19.7 <span style="font-family:symbol">&mu;</span>g/L; 95<sup>th</sup> percentile upper reference limit ,106.7 <span style="font-family:symbol">&mu;</span>g/L) or normalized to creatinine (median, 22.0 <span style="font-family:symbol">&mu;</span>g/g; 95<sup>th</sup>&nbsp;percentile upper reference limit,160.5 <span style="font-family:symbol">&mu;</span>g/g). When expressed as ratio to creatinine, NGAL values were higher in females&nbsp;than in males (median, 28.2 vs. 21.4 <span style="font-family:symbol">&mu;</span>g/g; 95<sup>th</sup> percentile upper reference limit, 199.7 vs. 169.5 <span style="font-family:symbol">&mu;</span>g/g), due to lower&nbsp;urinary creatinine concentrations in females.</p>
Biochimica Clinica ; 38(1) 18-22
Contributi scientifici - Scientific papers