Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
☩Howard Morris Australia
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
☩Jill Tate Australia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


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Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Arianna Lucini Paioni
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it



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BC: Articoli scritti da R. Pacifici

Quando ti porti il lavoro a casa: leggendo "tossicologia! Perchè ciò che non conosci ti può uccidere"
R. Pacifici  | 
<p>TRADUZIONE ITALIANA DI MARIO PLEBANI E MARIELA MARINOVA</p>
Biochimica Clinica ; 42(3) 274
Recensioni - Book Review
 
Droghe e alcol: tempo di armonizzazione
Alcohol and drugs: time for harmonization
Biochimica Clinica ; 39(2) 092-093
Editoriale - Editorial
 
“Smart drugs”, le nuove droghe sul web: due casi di intossicazione acuta
“Smart drugs”, the new drugs on the web: two cases of acute intoxication
<p>New psychoactive substances that&nbsp;in some cases are not subjected to any legal restriction recently overwhelmed web market. They were historically&nbsp;defined &ldquo;smart drugs&rdquo;: substances either natural or synthetic with alleged psychoactive effects as well as effects on&nbsp;sexual performance. We present here two intoxication cases: the first concernes a male subject hospitalized for deep&nbsp;unconsciousness, who took in yohimbine and kawaine, two psychoactive alkaloids present in herbal preparations of&nbsp;Pausinystalia yohimbe and Piper methysticum, sold on the sexy shop websites; the second concernes a female with&nbsp;a previous history of drug poliabuse, hospitalized for dysphoric syndrome/hallucinations, who took in benzydamine,&nbsp;a local anesthetic and analgesic drug, contained in an antibacterial gynecological powder that in oral mis-overdosage&nbsp;acts as a deliriant and central nervous system stimulant.</p>
Biochimica Clinica ; 38(3) 268-271
Casi clinici - Case report
 
Considerazioni sulle matrici biologiche idonee alla valutazione dell’“attualità d’uso di sostanze illecite” ai fini degli articoli 186 e 187 del nuovo Codice della Strada
Thoughts on biological matrices suitable for the assessment of "current use of illicit drugs" according to articles 186 and 187 of new Rules of the Road
R. Pacifici  |  P. Gori  |  L. Martucci  |  S. Pichini  | 
<p>Data on detection times of drugs of abuse in different biological&nbsp;matrices are based on pharmacokinetic studies in healthy volunteers during controlled clinical trials. The detection&nbsp;times mainly depend on the dose, route of administration, frequency of consumption (acute or chronic), detection limit&nbsp;of the assay employed for substance determination and matrix being analyzed (blood, saliva, urine, hair). Literature&nbsp;data agree that biologic effects drugs of abuse exert on the body match the presence of such substances and/or their&nbsp;metabolites in blood and/or saliva. Only after hepatic metabolism and renal excretion processes substances and/or&nbsp;their metabolites appear in urine, the last compartment from which substances are eliminated from the body. Hair&nbsp;analysis provides information on consumption of drugs of abuse in months prior to cutting of hair lock. These findings&nbsp;have relevance for the purposes of articles 186 and 187 of new Rules of the Road. Whereas in the case of alcohol,&nbsp;the law specifies in detail the biological matrix and the type of equipment to be used for the determination, for drugs&nbsp;of abuse it is unclear on what matrix is more appropriate to evaluate the presence of a substance of abuse and/or its&nbsp;metabolites in order to establish or better confirm driving under the influence of these substances. In this contribution,&nbsp;based on pharmacokinetic and pharmacodynamic considerations, we aim to reaffirm the most suitable biological&nbsp;matrices to determine the &quot;current use of illicit drugs&quot;.</p>
Biochimica Clinica ; 38(1) 27-31
Opinioni - Opinions
 
Determinazione di sostanze farmacologicamente attive lecite e illecite nel latte materno mediante cromatografia liquida - spettrometria di massa tandem
Liquid chromatography-mass tandem spectrometry assay (LC-MS/MS) for licit and illicit drugs in breast milk
Biochimica Clinica ; 35(4) 285
CONTRIBUTI SCIENTIFICI - CONTRIBUTI SCIENTIFICI
 
Documento di consenso Gruppo di Studio di Farmacotossicologia Clinica e Doping SIBioC e Gruppo Tossicologi Forensi (GTFI). Modalità per lo svolgimento di indagini di laboratorio per la determinazione delle sostanzed’abuso
Consensus document of the Study Group on Clinical Pharmacotoxicology and Doping of Italian Society ofClinical Biochemistry and Italian Forensic Toxicologists Group (GTFI) – for laboratories involved in thedetermination of substances of abuse
<p>The greatest workload for the laboratories performingpharmacotoxicological tests remains the routine activity for detection and measurement, in different biologicalmatrices, of psychotropic substances such as opiates, cocaine, cannabinoids, amphetamines, methadone,buprenorphine and ethyl alcohol. In addition to the investigations requested for clinical reasons, the requests to thepharmacotoxicological laboratories may also include medico-legal investigations, whose variety and complexitycontributed to the adoption of personalized and extremely diverse operating modalities implemented in the Italianlaboratories. The purpose of this document is to provide the Laboratories of the National Health Service in Italy thatare planning to carry out or that already perform determination of drugs of abuse for medico-legal purposes, withrecommendations at national level that take into account the &ldquo;good laboratory practices&rdquo; recognized at theinternational level in order to perform accurate and precise analytical tests so that they can meet the requirementsnecessary to provide a high quality and legally unassailable service.</p>
Biochimica Clinica ; 17(1)
Documenti SIBioC - SIBioC Documents