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BC: Articoli scritti da C. Ortolani

La diagnosi di malaria: ruolo dell’esame emocromocitometrico nello screening
The diagnosis of malaria: the role of the haematology analyzers as first level screening
R. Rolla  |  G. Da Rin  |  V. Granero  |  F. Dima  |  A. Fanelli  |  S. Francione  |  C. Ortolani  |  S. Pipitone  |  S. Buoro  | 
<p>The diagnosis of malaria: the role of the haematology analyzers as first level screening. Malaria is one of the three most common infectious diseases worldwide, and is caused mainly by four species of Plasmodium: P. falciparum, P. vivax, P. malariae and P. ovale. The disease is endemic in developing countries but it is also gradually involving Western Countries like Italy. Albeit in 1970 the World Health Organization has included Italy among the malaria-free countries, malaria has become the most frequently imported tropical disease.&nbsp; Microscopic examination of the peripheral blood smear is the gold standard for diagnosing malaria. Although this test is quick, cheap and readily applicable, it has also some drawbacks such as low sensitivity and the need of qualified personnel. Therefore, an effective screening test for detecting malaria in cases with low clinical suspicion or characterized by non-specific symptoms is increasingly necessary, especially in Countries where the disease is not endemic. A new generation of hematological analyzers, whose performance may be potentially useful for the screening of subjects with suspected malaria infection has made available. Many fully-automated hematological analyzers, using different techniques (optical-cytochemical, optical fluorescence, multiangle polarized dispersion and volume-conductance-scatter), can now identify the presence of the malarial parasites in peripheral blood, producing specific cell distributions. The blood count can hence be regarded as a new diagnostic opportunity in malaria infection, since it is one of the basic investigations performed in febrile patients, and is also a simple and fast test, that can be performed in virtually all clinical laboratories.</p>
Biochimica Clinica ; 42(3) 191-209
Rassegne - Reviews
 
Citometria a flusso ed ematologia oncologica: un matrimonio sempre valido
Flow cytometry and oncohematology: a relationship bound to last
C. Ortolani  |  B. Canonico  |  S. Papa  | 
<p>The contribution of flow cytometry to the&nbsp;diagnosis and follow-up of hematological neoplasms is of paramount importance and cannot be overstressed. Today,&nbsp;this relationship is not questioned and it is unlikely that the new molecular techniques will be able to replace it shortly.&nbsp;The reason of this long lasting success relies on the importance of phenotype in the diagnostic work-out, but above all&nbsp;on the flexibility of the technique, which is able to produce clinically relevant information in different situations, using&nbsp;smart fluorescence-based methods.</p>
Biochimica Clinica ; 40(3) 244-254
Opinioni - Opinions