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BC: Articoli scritti da G. Nordera

Effetti della restrizione calorica sullo stress ossidativo nell'obesità: sono miglioramenti transitori?
Effect of caloric restriction on oxidative stress in obesity: are these transient improvements?
A. Bolner  |  A. Vanzo  |  D. Giavarina  |  G. Nordera  |  O. Bosello  | 
<p>Background: the effects of caloric restriction (CR) on oxidative stress in obesity has been previously studied using markers that not always were able to describe all the components of the oxidative-inflammatory picture.<br />Methods: in this study, the redox state of 20 obese was evaluated at baseline and after 30 and 60 days of CR using a complete panel of markers: the majority of them were determined using HPLC methods.<br />Results: before CR (V0), serum peroxides (dROMs) were very high, total antioxidant barrier (BAP) was at the lower limit of the reference interval and C-reactive protein (hsCRP) was increased; on the opposite, glutathione was well within the reference intervals in both total and reduced form. Despite the imbalance of the dROMs/BAP equilibrium, the markers of oxidative damage, such 3-nitrotyrosine (3NT) and 8-hydroxy-deoxyguanosine (8OHdG), index of a mild oxidative-inflammatory imbalance, were not particularly relevant.<br />After 30 days of CR (V30), in addition to the slight improvements of glucose, fructosamine and HOMA-IR, hsCRP was decreased, while BAP and total glutathione were increased, with consequent improvement of the oxidative stress-inflammatory balance (oxidative-inflammation). After 60 days of CR (V60) the improvements observed at V30 appeared to be slowing down for glucose and fructosamine, in slight inverse tendency for HOMA-IR and hsCRP, and decreasing for BAP and glutathione. The slight increase of inter-quartile range (IQR) of 3NT showed a lower counter-regulatory antioxidant response capacity, as if the ameliorative effects of CR in the first period had turned off.<br />Conclusion: the improvements of the oxidative-inflammatory equilibrium appear to be transient in the course of CR. The rearrangements of the gut microbiota during CR and the consequent epigenetic modulations could be responsible for this peculiar trend.</p>
Biochimica Clinica ; 44(3) 232-238
Contributi Scientifici - Scientific Papers
 
Obesità, microbiota e stress ossidativo
Obesity, microbiota and oxidative stress
A. Vanzo  |  A. Bolner  |  G. Nordera  |  O. Bosello  | 
<p>Only in recent years, scientific societies and governments of many countries have considered obesity and its precursors, namely overweight, such as a disease that causes other diseases and reduces life quality and expectancy. According to the latest researches, obesity is a complex disease, with multifactorial etiology, not exclusively linked to eating disorders and lifestyle, which contribute inflammatory, infectious, toxic and also mental phenomena. Among many pathogenetic and pathophysiological invoked mechanisms, the effects of oxidative stress have recently received special attention. The imbalance between the production of free oxygen and nitrogen radicals and the physiological contrast mechanisms could actually play a causal role in the development of obesity by stimulating the deposition of white adipose tissue and altering the assumption of food. Oxidative stress and systemic inflammation are also key factors in the pathogenesis of obesity-related diseases, including atherosclerosis, insulin resistance, type 2 diabetes and cancer. Despite the correlation between obesity and oxidative stress, none of the biochemical markers of oxidative damage can be considered predictive of obesity; on the contrary, some markers seem to predict the development and progression of cardiovascular and metabolic disease in overweight and obese subjects. Recent observations also demonstrate the existence of quantitative and qualitative differences in the intestinal microbiota between individuals at high and low risk of development of obesity and related complications. Therefore, the intestinal microbiota might play a key role in the pathogenesis of obesity.</p>
Biochimica Clinica ; 41(3) 199-207
Rassegne - Reviews