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BC: Articoli scritti da B. Morelli

La variabilità preanalitica in coagulazione
Pre-analytical issues in coagulation testing
<p>Poor standardization of preanalytic variables influences greatly thereliability of coagulation testing, consuming health care resources and compromising patient outcomes. Thesevariables include patient preparation, sample collection, handling, transportation, processing, and storage until timeof analysis: lack of standardized procedures for sample collection accounts for most of the errors encountered withinthe total testing process. Most pre-analytical problems may arise from system faults and insufficient audit of theoperators involved in specimen collection and handling, leading to unsuitable specimens due to misidentification,hemolysis, clotting, inappropriate volume, wrong container, contamination from the infusive route. Detection,acknowledgement and management of pre-analytical variables, is mandatory for delivering accurate laboratoryresults. The present document, issued by the Study Group on Haemostasis of the Italian Society of LaboratoryMedicine, is a summary of the recommendations for standardisation of the pre-analytical phase of the coagulationtesting, related to sample collection, transportation, and storage and provides guidance to reduce the effects of pre-analytical issues that can have a significant impact on patient care.</p>
Biochimica Clinica ; 43(3) 313-326
Documenti SIBioC - SIBioC Documents
 
Indagine sulla modalità di refertazione dell’esame D-dimero nei laboratori nazionali e indicazioni per una sua armonizzazione
A survey on D-dimer test reporting in Italian laboratories and some suggestions for its harmonization
G. Lippi  |  B. Morelli  |  A. Tripodi  | 
<p>D-dimer&nbsp;assessment represents a cornerstone in the diagnostic approach and therapeutic management of several thrombotic&nbsp;disorders, namely venous thromboembolism and disseminated intravascular coagulation. Nevertheless, this test is still&nbsp;plagued by an insufficient degree of analytical and post-analytical standardization. In particular, despite the existence&nbsp;of national guidelines, result reporting is quite heterogeneous. A specific on-line, 5-item questionnaire was&nbsp;disseminated to the SIBioC members to obtain a picture of the current national situation. As regards to the units, a&nbsp;modest prevalence (53%) of D-dimer unit (DDU) over fibrinogen equivalent unit (FEU) (47%) was found. The most&nbsp;widespread measurement unit was &ldquo;ng/mL&rdquo; (60%), followed by &ldquo;&mu;g/L&rdquo; (18%), &ldquo;mg/L&rdquo; (15%) and &ldquo;&mu;g/mL&rdquo; (6%). The vast&nbsp;majority of laboratories (90%) did not use an age-adjusted cut-off. The data distribution did not differ among different&nbsp;types of healthcare settings (i.e., general hospital, university hospital or private facilities). The use of at least 16 different&nbsp;unit approaches for D-dimer emerged from the survey is quite alarming and calls for a standardization, using a single&nbsp;result reporting as .</p>
Biochimica Clinica ; 39(6) 591-594
Contributi scientifici - Scientific Papers
 
Documento di consenso di “Academy of Emergency Medicine and Care”, Comitato Italiano per la Standardizzazione dei Metodi Ematologici e di Laboratorio, SIBioC - Medicina di Laboratorio e Società Italiana di Medicina di Laboratorio sull’utilizzo del dosaggi
Consensus document of Academy of Emergency Medicine and Care, Italian Committee for Standardization of Hematology and Laboratory Methods, SIBioC-Laboratory Medicine and Italian Society of Laboratory Medicine on D-dimer testing for suspected venous thrombo
G. Lippi  |  I. Casagranda  |  B. Morelli  |  S. Testa  |  A. Tripodi  | 
<p>The&nbsp;assessment of D-dimer represents the biochemical standard for diagnosing venous thromboembolism (VTE) and it&nbsp;is hence included in all diagnostic algorithms. Despite the unquestionable diagnostic value, there is broad evidence&nbsp;that the clinical usefulness of D-dimer may be biased by preanalytical, analytical and post-analytical issues. This is&nbsp;particularly true in emergency departments, where a large number of patients with suspected VTE is admitted, triaged&nbsp;and managed. Therefore, representatives of societies listed in the title have drafted this consensus document aimed&nbsp;to cover the most important critical areas in D-dimer testing, providing tentative recommendations to improve its&nbsp;clinical effectiveness for diagnosing VTE in the emergency department.</p>
Biochimica Clinica ; 38(2) 136-138
Documenti SIBioC - SIBioC Documents
 
Il laboratorio e i nuovi anticoagulanti orali
Laboratory and new oral anticoagulants
B. Morelli  |  E. Ascari  | 
<p>Heparins and vitamin K antagonists are drugs of choice for treatment and&nbsp;prevention of thrombotic pathologies. These drugs have a considerable degree of safety and efficacy, but they may&nbsp;present certain drawbacks, as they require frequent laboratory monitoring (unfractionated heparins and anti-vitamin&nbsp;K) or intravenous or subcutaneous administration (low molecular weight heparins). Due to these reasons, several&nbsp;studies have been performed to identify new anticoagulant drugs with characteristics of safety, efficacy and possibility&nbsp;of oral administration and no need of laboratory monitoring. New direct oral anticoagulants (DOAs) have as direct&nbsp;target thrombin (factor IIa) or factor-Xa inhibition; their safety and efficacy have been investigated in several phase&nbsp;III studies. DOAs in most advanced stage of release are dabigatran, rivaroxaban and apixaban; the first drug is a&nbsp;direct thrombin inhibitor, the others are direct factor-Xa inhibitors. DOAs do not require routine laboratory monitoring&nbsp;due to their high dose-response predictability; there is, however, a necessity to measure their anticoagulant effect in&nbsp;some particular situations. In those situations, it is important for the laboratory to consider: 1) how DOAs can interfere&nbsp;in the measurement of basic and more specialistic coagulation parameters; 2) which tests are the most suitable to&nbsp;detect the presence of the new drug; 3) which tests are the most useful to measure the anticoagulant effect; 4) which&nbsp;tests are the most suitable to monitor the antagonizing effect of some drugs (&quot;reversal&quot;) in case of DOA overdose.</p>
Biochimica Clinica ; 37(4) 292-300
Documenti - Documents
 
Raccomandazioni per la diagnosi di laboratorio della malattia di von Willebrand
Recommendations for the laboratory diagnosis of von Willebrand disease
B. Morelli  |  F. Stufano  | 
<p>Von Willebrand disease (VWD) is the most common inherited bleeding disorder. Clinically, VWD induces mucosal bleeding caused by a decreased quantity or quality of von Willebrand factor (VWF). Diagnosis of VWD requires careful consideration of patient specific factors, bleeding symptoms, and laboratory results. There is no single diagnostic test for VWD; laboratory diagnosis requires a number of assays of VWF amount and function, and factor VIII activity, with no single straightforward diagnostic test available up to know to either confirm or exclude the diagnosis. The currently available laboratory testing for VWD is imperfect, but if accompanied by an attentive and careful interpretation provides significant clinical utility by categorizing affected patients by type of VWD. As the diagnosis of VWD variants has implications fort reatment, laboratory testing is therefore critical for optimising patient care. Newer assays of VWF function are becoming available and will be of great help in establishing the laboratory diagnosis of VWD.</p>
Biochimica Clinica ; 17(1)
Documenti - Documents