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BC: Articoli scritti da G. Molon

Dabigatran e analisi di laboratorio
Dabigatran and laboratory tests
R. Facchinetti  |  B. Capizzi  |  B. Caruso  |  M. Negri  |  R. Suppi  |  G. Molon  |  G.C. Guidi  | 
<p>New oral anticoagulants (i.e., dabigatran, rivaroxaban, apixaban) are now&nbsp;available. In using these drugs, routine monitoring of laboratory coagulation tests is not recommended. In some&nbsp;clinical conditions, however, a laboratory evaluation of hemostatic balance may be useful. Tests suggested for&nbsp;laboratory monitoring of dabigatran treatment are thrombin time on undiluted (TT) or diluted (dTT) plasma and ecarin&nbsp;clotting time. On 30 patients taking dabigatran for non valvular atrial fibrillation, we assayed dabigatran levels by dTT,&nbsp;also performing prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and TT. In patients&nbsp;taking dabigatran etexilate 110 mg bis in die and 150 mg bis in die, dTT mean results (10<sup>th</sup>-90<sup>th</sup> percentile) were 97&nbsp;(32-152) and 94 (33-189) &mu;g/L, respectively. In dTT range from 13 to 60 &mu;g/L and &gt;60 &mu;g/L, we obtained 27% and&nbsp;58% prolonged PT, 64% and 95% prolonged APTT, and 100% and 100% prolonged TT, respectively, showing that for&nbsp;dabigatran TT is a useful screening test.</p>
Biochimica Clinica ; 39(1) 041-047
Contributi scientifici - Scientific Papers