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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Andrea di Bello
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da C. Mandoj

Prolungamento del tempo di tromboplastina parziale attivata in una paziente asintomatica: la carenza di precallicreina
Prolonged activated partial thromboplastin time in an asymptomatic patient: the prekallikrein deficiency
<p>Prekallikrein (PK) is a contact factor of the intrinsic pathway of the coagulation cascade. Patients with PK deficiency&nbsp;usually do not show a bleeding tendency despite a prolonged activated partial thromboplastin time (aPTT) test. Here&nbsp;we report a case of a 72-years-old Caucasian woman manifesting a prolonged aPTT test. The aPTT correction after&nbsp;1:1 mixing with normal pool plasma (NPP) indicated a coagulation factor deficiency; however factors XII, XI, IX and VIII&nbsp;activities were normal. A 100:1 mixing with NPP was performed, resulting in an aPTT test correction; the aPTT test was&nbsp;then performed increasing the pre-incubation time of the patient&rsquo;s plasma. This resulted in a significant reduction of the&nbsp;aPTT. The PK deficiency was ultimately confirmed by direct measurement of PK plasma activity. This experience&nbsp;shows that PK deficiency should be considered for asymptomatic patients with prolonged aPTT and that, whenever a&nbsp;PK deficient plasma is not available, the diagnosis can be correctly oriented on the basis of simple aPTT tests.</p>
Biochimica Clinica ; 39(4) e7-e9
Casi clinici - Case report