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Giuseppe Agosta

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BC: Articoli scritti da C. Mandoj

Prolungamento del tempo di tromboplastina parziale attivata in una paziente asintomatica: la carenza di precallicreina
Prolonged activated partial thromboplastin time in an asymptomatic patient: the prekallikrein deficiency
<p>Prekallikrein (PK) is a contact factor of the intrinsic pathway of the coagulation cascade. Patients with PK deficiency&nbsp;usually do not show a bleeding tendency despite a prolonged activated partial thromboplastin time (aPTT) test. Here&nbsp;we report a case of a 72-years-old Caucasian woman manifesting a prolonged aPTT test. The aPTT correction after&nbsp;1:1 mixing with normal pool plasma (NPP) indicated a coagulation factor deficiency; however factors XII, XI, IX and VIII&nbsp;activities were normal. A 100:1 mixing with NPP was performed, resulting in an aPTT test correction; the aPTT test was&nbsp;then performed increasing the pre-incubation time of the patient&rsquo;s plasma. This resulted in a significant reduction of the&nbsp;aPTT. The PK deficiency was ultimately confirmed by direct measurement of PK plasma activity. This experience&nbsp;shows that PK deficiency should be considered for asymptomatic patients with prolonged aPTT and that, whenever a&nbsp;PK deficient plasma is not available, the diagnosis can be correctly oriented on the basis of simple aPTT tests.</p>
Biochimica Clinica ; 39(4) e7-e9
Casi clinici - Case report