Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
☩Howard Morris Australia
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
☩Jill Tate Australia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Arianna Lucini Paioni
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it



Area soci
Non possiedi o non ricordi la password!
Clicca qui

BC: Articoli scritti da M. Malaguarnera

Attività fisica e biomarcatori dello stress ossidativo nell’invecchiamento
Physical exercise and oxidative stress biomarkers in the elderly
<p>Introduction: aging is regulated by a number of aging genes including sirtuins, linked to redox status and epigenetically controlled. Physical exercise, depending on intensity, type of training and duration, seems to modulate positively the redox state in aging. It was demonstrated an increase in susceptibility to oxidative stress by the depletion of intracellular glutathione (GSH) and total glutathione (tGSH) levels in the muscles of aged animals. Moreover, physical activity, especially if moderate and regular, seems to activate adaptive mechanisms, reducing body&#39;s vulnerability to oxidative stress and improving systemic metabolic activities.<br />Methods: this study is aimed to evaluate the effects of regular exercise (3 times/week for 2 months) on the levels of radical species (d-ROM test), thiol groups (SHp test), plasma antioxidant capacity (BAPtest), 8-OH-guanosine (COMET test) and some redox-related proteins (HSP27, HSP70, Sirt1 and 2) in 40 healthy elderly subjects, aged from 65 to 74 years. In addition, plasma enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were evaluated.<br />Results: the enrolled subjects showed oxidative stress before exercise with the presence of radical species, oxidation of purine bases and reduced antioxidant capacity. After the scheduled training, a global improvement of oxidative stress markers was observed with an upregulation of HSP27, HSP70, Sirt1 and Sirt2 expression, as adaptive response.<br />Conclusion: our results underline the importance of these biochemical parameters to monitor oxidative stress in aging and the adaptive redox response to physical exercise in elderly.Therefore, these biomarkers may be routinely used in order to identify individuals at risk for developing oxidative stress related pathologies as well as in personalized physical therapy.</p>
Biochimica Clinica ; 17(1)
Contributi Scientifici - Scientific Papers