Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

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Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
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Giuseppe Lippi Italy
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BC: Articoli scritti da V. Granero

Astenia e urine intensamente colorate: una associazione da indagare attentamente
Asthenia and extremely colored urine: an association to be investigated carefully
<p>Autoimmune hemolyticanemia (AIHA) is a relatively rare disease where red blood cells are selectively destroyed by auto-antibodies. Ingeneral, direct antiglobulin test (DAT) is the test used for confirmation even if there are other markers to guide thedifferential diagnosis and to evaluate the degree of hemolysis. We present a case of severe warm-type AIHA occurredin a thirty-six year old man with initial symptoms of asthenia and dark urine. The case shows how specialists inlaboratory medicine can play a fundamental role in the diagnostic process through an appropriate use of the tests,speeding up the management of the patient, improving thus the prognosis.</p>
Biochimica Clinica ; 43(2) e009-e011
Casi Clinici - Case Report
La diagnosi di malaria: ruolo dell’esame emocromocitometrico nello screening
The diagnosis of malaria: the role of the haematology analyzers as first level screening
R. Rolla  |  G. Da Rin  |  V. Granero  |  F. Dima  |  A. Fanelli  |  S. Francione  |  C. Ortolani  |  S. Pipitone  |  S. Buoro  | 
<p>The diagnosis of malaria: the role of the haematology analyzers as first level screening. Malaria is one of the three most common infectious diseases worldwide, and is caused mainly by four species of Plasmodium: P. falciparum, P. vivax, P. malariae and P. ovale. The disease is endemic in developing countries but it is also gradually involving Western Countries like Italy. Albeit in 1970 the World Health Organization has included Italy among the malaria-free countries, malaria has become the most frequently imported tropical disease.&nbsp; Microscopic examination of the peripheral blood smear is the gold standard for diagnosing malaria. Although this test is quick, cheap and readily applicable, it has also some drawbacks such as low sensitivity and the need of qualified personnel. Therefore, an effective screening test for detecting malaria in cases with low clinical suspicion or characterized by non-specific symptoms is increasingly necessary, especially in Countries where the disease is not endemic. A new generation of hematological analyzers, whose performance may be potentially useful for the screening of subjects with suspected malaria infection has made available. Many fully-automated hematological analyzers, using different techniques (optical-cytochemical, optical fluorescence, multiangle polarized dispersion and volume-conductance-scatter), can now identify the presence of the malarial parasites in peripheral blood, producing specific cell distributions. The blood count can hence be regarded as a new diagnostic opportunity in malaria infection, since it is one of the basic investigations performed in febrile patients, and is also a simple and fast test, that can be performed in virtually all clinical laboratories.</p>
Biochimica Clinica ; 42(3) 191-209
Rassegne - Reviews
L’utilità della revisione microscopica nella diagnostica della malaria: un’infezione sub-microscopica da Plasmodium falciparum
The usefulness of microscopic review in the diagnosis of malaria: a sub-microscopic infection by Plasmodium falciparum
<p>Malaria is a major global health problem. The clinical diagnosis must be confirmed by laboratory tests. However, the research of malarial plasmodia is performed only in case of clinical suspicion, while it should be used with greater awareness given the increase of the migratory phenomena towards Europe in recent years. We present a case of Plasmodium falciparum infection with a parasitemia of 1/1500 red blood cells in a young immigrant from Burkina Faso carrier of a HbC variant hemoglobin without any alterations to the blood count. The case shows how microscopic revision is a fundamental diagnostic element; the detection of a hemoglobin variant made possible to understand the dynamic of the infection in order to be able to assure to the patient the best therapeutic treatment.</p>
Biochimica Clinica ; 42(3) e43-e45
Casi clinici - Case report