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Giuseppe Agosta

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BC: Articoli scritti da GdS SIBioC - Medicina di Laboratorio Marcatori Cardiaci

Rilevanza clinica e interpretazione dei marcatori biochimici nello scompenso cardiaco
Clinical relevance and interpretation of biochemical markers in heart failure
<p>Heart failure (HF) is a global&nbsp;problem with an estimated prevalence of 38 million patients worldwide. Both prevalence and incidence of HF increase&nbsp;progressively with population ageing (prevalence &ge;10% in people &gt;75 years), especially in the high-income countries.&nbsp;HF is considered as the fatal event of all cardiovascular disorders. Despite some progress in diagnosis and treatment,&nbsp;its prognosis is worse than that of most cancers. The disease is heterogeneous in its clinical presentation and the&nbsp;diagnosis is not based on a single test, but on a combination of the history, physical examination and appropriate&nbsp;investigations, including some laboratory tests. As a consequence, the accuracy of diagnosis by clinical signs alone&nbsp;is often inadequate, especially in the early asymptomatic stage of HF. For these reasons, there is an increasing&nbsp;interest in the development of new biomarkers useful for the diagnosis, prognosis and follow-up of patients with HF.&nbsp;The aim of this paper is to provide an overview of biomarkers recommended by international guidelines for HF,&nbsp;discussing their clinical impact and the interpretation of results. Furthermore, a possible strategy for the development&nbsp;and evaluation of novel prognostic biomarkers for HF will be suggested.</p>
Biochimica Clinica ; 39(4) 241-255
Rassegne - Reviews