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Giuseppe Agosta

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Arianna Lucini Paioni
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BC: Articoli scritti da L. Colacicco

Is there a role for serum cystatin C as a biomarker of multiple sclerosis?
<p>Multiple sclerosis (MS) is the most common chronic demyelinating disorder of the central nervous system (CNS). No&nbsp;single clinical feature or diagnostic test is sufficient for the diagnosis of MS and the clinical assessment is very difficult,&nbsp;mainly at the early disease stages. Considering MS as a disorder confined to CNS compartment and related to CNS&nbsp;specific pathogenetic pathways, several studies selectively investigated cerebrospinal fluid (CSF) components to&nbsp;detect predictive/prognostic MS markers. Several molecules, such as CSF 14-3-3 protein, tau protein and cystatin C,&nbsp;have been found dysregulated, even though with discordant results. We analyzed serum and CSF cystatin C&nbsp;concentrations of MS patients, comparing them with results obtained from individuals affected by other neurological&nbsp;diseases. We found no statistical differences between groups in CSF cystatin C, cystatin C difference (<span style="font-family:symbol">D</span><sub>CystC</sub> = CSF&nbsp;- serum cystatin C) and ratio (CystC<sub>ratio</sub> = CSF/serum cystatin C). Interestingly, serum cystatin C concentrations of&nbsp;MS patients resulted significantly lower than in control population [0.71 (interquartile range, 0.64-0.84) mg/L vs. 0.80&nbsp;(0.67-0.93) mg/L, P=0.008], with no gender-related differences. The pathophysiologic explanation of this finding is&nbsp;unclear, although it cannot be excluded that pathologic mechanisms that lead to MS may involve not only the CNS&nbsp;compartment, but also systemic pathogenetic pathways.</p>
Biochimica Clinica ; 38(3) 218-221
Contributi scientifici - Scientific Papers