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BC: Articoli scritti da A. Caleffi

Esame fisico, chimico e morfologico delle urine: proposta di linee guida per la fase analitica del Gruppo Intersocietario Analisi delle Urine (GIAU)
Physical, chemical and morphological urine examination: proposed guidelines for the analytical phase by the Intersociety Urinalysis Group
<p>With these guidelines, the Intersociety Urinalysis Group (GIAU) aims to stimulate the following aspects: a) improvement and standardization of the analytical approach to physical, chemical and morphological urine examination (ECMU); b) to emphasize the value added to ECMU by automated analyzers for the study of the morphology of the corpuscular fraction urine; c) improvement of the chemical analysis of urine with particular regard to the reconsideration of the diagnostic significance of parameters that are traditionally evaluated in dipstick analysis, together with an increasing awareness of the limits of sensitivity and specificity of this analytical method; d) to increase the awareness of the importance of professional skills in the field of urinary morphology and of the relationships with clinicians; e) implementation of a policy for the evaluation of the analytical quality by using, in addition to traditional IQC and EQA, a program for the evaluation of morphological competence; f) to stimulate the diagnostic industry to focus research efforts and development methodology and instrumental catering to the needs of clinical diagnosis. The hope is to revalue the enormous diagnostic potential of ECMU, by implementing an urinalysis based on personalized diagnostic needs.</p>
Biochimica Clinica ; 40(4) 353-382
Documenti SIBioC - SIBioC Documents
Identificazione casuale di atrofia gastrica severa con macrocitosi complicata da sindrome coronarica acuta
Casual identification of severe gastric atrophy with macrocytosis complicated by acute coronary syndrome
<p>Chronic atrophic gastritis (CAG) and gastric cancer are leading causes of morbidity and mortality worldwide. Serum&nbsp;pepsinogens have been used as biomarkers of gastric mucosa status, including gastric inflammation, so that they&nbsp;might be useful for detection of gastric atrophy or gastric neoplasm at an early stage. Serum pepsinogen 1 and&nbsp;pepsinogen 2 concentrations are known to increase in the presence of <em>Helicobacter pylori</em>-related non-atrophic chronic&nbsp;gastritis, and the eradication of this pathogen is associated with a significant decrease in their values. We describe here&nbsp;the case of an asymptomatic 60 years old man, with a casual serological diagnosis of severe gastric atrophy,&nbsp;macrocytosis and severe complications, culminating in an acute coronary syndrome. This case report raises some&nbsp;important considerations, such as the fact that CAG could not be correctly and early diagnosed and that it may be&nbsp;misleadingly regarded as a rare condition, whereas its prevalence is conversely largely underestimated. This may lead&nbsp;to severe complications that may include gastric malabsorption and vitamin B<sub>12</sub> deficiency, along with gastrointestinal,&nbsp;neurologic, psychiatric, cardiovascular, cerebral and peripheral vascular disorders.</p>
Biochimica Clinica ; 39(1) 068-072
Casi clinici - Case report
Automated screening of bacterial meningitis by cytofluorimetric analysis of cerebrospinal fluid: preliminary results
<p>This study was planned to assess the diagnostic performance of the automated urine particle analyzer Sysmex UF-1000i for the rapid screening of cerebrospinal fluid (CSF) in patients with suspected meningitis. Cytometric analyses&nbsp;with either optical microscopy (OM) or UF-1000i, along with assessment of glucose and protein in CSF, were performed&nbsp;on 101 consecutive CSF of patients with suspected meningitis. In 50 out of 101 samples, cultural analysis was also&nbsp;performed with different culture media. Four different diagnostic combination were developed, with different mix of the&nbsp;tested parameters. A high correlation was found between OM and UF-1000i (r=0.99; mean bias, -4.9/&mu;L). The&nbsp;diagnostic agreement was 0.90 in adults and 0.97 in children. The diagnostic agreement between CSF culture and&nbsp;bacterial count by UF-1000i was 0.98, with 1.00 sensitivity and 0.98 specificity. Results showed that the diagnostic&nbsp;combination based on CSF glucose and total proteins, cytometric analysis (leukocyte count &plusmn; neutrophilia) and&nbsp;bacterial count on UF1000i exhibited the best performance when compared with microbiological examination (area&nbsp;under ROC curve, 1.00). In conclusion, the results of this study show that the combination of two rapid clinical&nbsp;chemistry tests such as glucose and total proteins with UF-1000i analysis could represent a valid approach for&nbsp;supporting more complex analyses or even for replacing OM and CSF culture during stat examination and to achieve&nbsp;a quick detection of central nervous system infections.</p>
Biochimica Clinica ; 38(3) 208-212
Contributi scientifici - Scientific Papers
L'esame chimico, morfologico e colturale delle urine: proposta di linea guida peruna procedura standardizzata della fase preanalitica
Chemical, morphological, and microbiological urine examination: a proposal of guidelines for standardization of preanalytical phase.
Biochimica Clinica ; 35(2) 131