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BC: Articoli scritti da M. Berardi

Lab Tests Online: un successo che parte da lontano
M. Berardi  | 
Biochimica Clinica ; 43(2) 245-247
Notizie SIBioC - SIBioC News
 
Un caso di mieloma multiplo IgG kappa in cui la misura delle catene leggere libere ha evidenziato precocemente una ripresa di malattia di tipo “light chain escape”
A case of IgG kappa multiple myeloma where the measurement of the free light chains was an early marker of a “light chain escape” relapse
<p>Light chain escape (LCE) is a type of relapse where a serum free light chains (FLC) increase is observed, in the absence of a parallel increase of the original monoclonal component; this particular kind of relapse seems to be influenced by new therapeutic regimens. We present a case of a 55-years old man with a IgG kappa multiple myeloma (MM), who underwent double autologous bone marrow transplantation as first line therapy; after relapse, the patient was treated with lenalidomide/dexamethasone (LD). After more than three years of LD treatment, in September 2014, an increase of FLCs was observed, while serum and urine immunofixations remained negative until January and February 2015 respectively, when a LCE was diagnosed. Despite the new treatment, the patient died in June 2016. The FLCs measurement, although not reaching the IMWG criteria, detected relapse earlier than immunofixation. This case indicates that FLCs should be routinely performed during follow up of MM patients to ensure that LCE is not missed.</p>
Biochimica Clinica ; 41(3) e22-e24
Casi clinici - Case report
 
Armonizzazione in Medicina di Laboratorio
Harmonization in Laboratory Medicine
Biochimica Clinica ; 39(6) 546-547
Editoriale - Editorial
 
Un caso di gammopatia monoclonale di significato renale in un paziente con glomerulopatia immunotattoide
A case of monoclonal gammopathy of renal significance in a patient affected by immunotactoid glomerulopathy
<p>Monoclonal gammopathy of renal significance is defined by the causal relationship between a small&nbsp;B-cell clone and the renal disease. Immunotactoid glomerulopathy is a rare glomerular disease characterized by<br />highly organized crystalline structure of Congo Red-negative immune deposits in the absence of systemic disease.&nbsp;We describe a 54 years-old man with non-nephrotic proteinuria and chronic renal failure. Laboratory findings revealed&nbsp;a serum monoclonal component. Renal histology showed a morphological pattern of membrano-proliferative&nbsp;glomerulonephritis; electron microscopy evidenced micro tubular structures within the mesangium measuring&nbsp;approximately 20 nm in thickness, similar to cryoglobulins. Renal immunofluorescence demonstrated in the deposits&nbsp;the same monoclonal component observed in serum, leading to a final diagnosis of immunotactoid glomerulopathy.</p>
Biochimica Clinica ; 39(6) e22-e24
Casi clinici - Case report
 
Valutazioni preliminari per la proposta di un unico dispositivo di campionamento per la ricerca dell’emoglobina su materiale fecale
Preliminary assessments for a standard sampling device for fecal hemoglobin detection
S. Rapi  |  C.G. Fraser  |  F. Cellai  |  M. Berardi  |  T. Rubeca  | 
<p>Sampling of feces is&nbsp;strongly affected by the lack of harmonisation, with differences up to 20 times in the mass collected for immunological&nbsp;tests for fecal hemoglobin (Hb) used in colorectal cancer screening. Aim of this study was to acquire information on&nbsp;fecal sampling and on the interaction between feces and analytical methods to obtain a reference design for a&nbsp;sampling dipstick. Bias and imprecision of sample collection dipsticks were estimated using gravimetry. Dissolution&nbsp;times of feces were monitored throughout the study. The effect of increasing amount of feces on Hb concentrations&nbsp;was investigated in saline and buffers of different manufacturers using a single analytical method (OC-Sensor, Eiken&nbsp;Chemical Co.). Fecal mass recovered with different devices ranged from 56 to 121% of declared amount (CV range:&nbsp;8.6&divide;31.1%). Time of dissolution up to 2 h was observed when lumps of materials were collected. In saline a rapid&nbsp;decrease of Hb values was observed, which was related to the overall amount of feces. Increased Hb values were<br />observed by adding feces to manufacturers&rsquo; buffers. Solubilisation time, bias and imprecision of sampling of feces&nbsp;were related to device design. Analytical methods are designed to use specific ratios between feces and buffers. The&nbsp;introduction of a standard dipstick design to reduce preanalytical variability may represent a crucial step for fecal test&nbsp;harmonization.</p>
Biochimica Clinica ; 39(6) 563-567
Contributi scientifici - Scientific Papers